Alan Frazier

A 600-pound man is admitted to the hospital after he is found in his apartment in a coma. House and his team must look past their obese patient’s exterior in order to diagnose his illness.

During an encounter with a violent beggar, Matthew is saved by Jimmy's archrival, Johnny Johnson. Though Jimmy made sure he was penniless following the attempt to gain control of the company, Johnny is still determined to make good on his promise to marry Lisa. But, while everyone else is convinced that it's Lisa he wants, Joe is certain that Johnny has other motives in mind. While disappointed to learn that he didn't completely crush Johnny, Jimmy offers to help him in his quest for Lisa. And when Joe accuses him of plotting to destroy Jimmy's empire, Johnny makes it clear that he isn't a threat. However, after helping to get Johnny cleaned up, Jimmy enlists Lisa in another effort to break him. And though she tries, Lisa cannot resist Johnny's charms. Realizing that she's too weak to say no, Dave agrees to deliver Lisa's refusal to Johnny. With Joe continuing to carefully guard Jimmy's interests, Johnny insists on hearing Lisa turn him down in person. But when she finds the strength to do it, Jimmy and Max accuse her of being heartless. Finally, as everyone searches the local subway station for him in order to apologize, Johnny's charms are too much for Lisa to resist.

As Lisa asks Jimmy to stand in and give her away when her father refuses to attend her wedding, Dave sets out to persuade her not to marry Johnny Johnson. However, Dave's efforts are set back when Johnny asks him to be the best man. And though Lisa admits that marrying Johnny is irrational, she still refuses to reconsider. Meanwhile, as Matthew throws a bachelor party at work, Dave agrees to be the best man, if only to keep the honor from going to Max. Once everyone arrives at Jimmy's estate for the wedding, Dave does his best to move things along to where he can object to the union. But even Dave's pointing out that the groom is a homeless drunk fails to derail the marriage. However, when he and Lisa are pronounced man and wife, Johnny is arrested and taken to jail when the ring he gave her turns out to be stolen. Although Jimmy offers the best lawyers money can buy, Johnny chooses to accept his punishment. Admitting that Dave was right all along, Lisa wants the marriage annulled. But when Dave makes a humorous observation about the bright side of having a husband in prison, she changes her mind. Finally, still unable to set aside her feelings for Johnny, Lisa takes everyone to the jail to finish the wedding, even as Dave tries getting her to reconsider one last time.