As the Otto family ushers in a new era, Katie and Greg make the emotional decision to sell the family minivan; Daniel suffers a setback that forces him to rethink how to accomplish his goals.
Meredith, Richard and Alex must deal with the consequences after Bailey fires them for insurance fraud; after disappearing in the fog, Jackson helps a man in a dangerous situation; Tom gets new responsibilities at the hospital.
Meredith works on a patient who happens to specialize in matchmaking, and a seemingly drunk patient pushes Richard's buttons and gives him a medical mystery to solve. Meanwhile, Maggie tries to reach Teddy after bearing the burden of her secret becomes overwhelming as she struggles with issues in her own personal life.
A patient gives Meredith some clarity on her dating situation around the holidays. The strain on Bailey and Ben's marriage comes to a head. Meanwhile, Betty drops a bomb on Owen and Amelia.
Meredith reaches out to Teddy and helps her talk through some of her personal struggles. Owen and Amelia hide out near Betty's school after she becomes a flight risk. Meanwhile, Jo wants to get to work on the fellowship, but Bailey's attention is elsewhere.