Sherlock resumes his hunt for Moriarty when Sebastian Moran reveals that a man who was thought to be dead from a heart attack was actually on the list of intended victims from Moriarty. Vinnie Jones returns as the sinister "M." F. Murray Abraham guest stars as "The Actuary," a devious hitman.
Lucca defends a TV writer-producer in a copyright infringement case with ties to the President of the United States. Mike Kresteva takes aim at Reddick, Boseman & Kolstad. Carrie Preston, Matthew Perry and John Benjamin Hickey guest star.
A couple faces trial after they deny medical help to their daughter based on their religious beliefs and Stone's prosecution hinges on whether or not the parents wanted to call for medical help. Things take a turn when the investigation uncovers another child that died under similar circumstances.
In a "ripped from the headlines" episode, an attack on a pro tennis player leads detectives Briscoe (Jerry Orbach) and Logan (Chris Noth) to a crazed fan. Further questionning reveals an interesting twist - that the attacker wasn't the crazed fan, but a rival player working under instructions from the victim herself. John Heard (Home Alone) guest stars.
The death of a show horse seems a more likely case for the ASPCA then Briscoe and Curtis, until a shady horse dealer is accused of selling sick horses to unsuspecting, older investors. Later, Kincaid and McCoy push for a conviction when the horse's owner disappears and is presumed dead.