Trying to guide a lost wagon train, Cheyenne and Smitty tangle with a gang of cattle rustlers.
Pat Keogh is a bank robber and killer who, when the episode begins, has just killed a man and Cheyenne has been accused by a group of vigilantes.
When he is unable to save his own father, Diablo's town doctor loses his confidence in himself. It's up to Annie to convince him that Diablo needs him and that you must get right back up when you're knocked down.
Lofty's niece Penny arrives on a stage that's been robbed and Tagg is envious because she's better at activities. Annie and Lofty are unable to solve the crime but the youngsters discover a lead but need the help of Hector, Tagg's frog.