When NASA reschedules Howard's mission and puts his wedding plans in jeopardy, he's forced to face his fears and Bernadette's dad (guest star Casey Sander). Meanwhile, Leonard says something surprising to Penny in the bedroom.
A scheming Frasier finally works his way into hosting the annual televised Christmas parade but he is horrified to learn that his wildly successful protege - the sassy, brassy radio host known as Dr. Mary will be his substitute co-host, prompting a battle royale for control of the microphone.
When a prominent astrophysicist is found dead in her car, Castle is led to theorize her death was the result of an alien abduction.
Paul stands in the way of Susan receiving a kidney transplant; Tom passes up a lucrative job to continue working with Carlos; Andrew's alcohol consumption increases, worrying Bree.
Bailey treats a young mother battling breast cancer; Derek learns more about Mark and Addison's relationship; the interns defend a resident's competence at a staff meeting.
