When a history-making blizzard hits New York, Max (Ryan Eggold) and his staff must work together to keep their patients safe with little resources, even if it means taking to the streets of the city and braving the storm.
Max (Ryan Eggold) is forced to reckon with his diagnosis in a new way as things become more difficult for him. Meanwhile, Reynolds (Jocko Sims) is forced to address what could have gone wrong in a recent surgery.
As a monster hurricane approaches New York, Bloom and the team scramble to put preparations in place. Max and Helen make plans for an intimate New York wedding as she returns from London. Iggy and Martin reach a crossroads. Reynolds finally makes contact with his father.
New Amsterdam is still reeling from the pandemic as a plane crash lands in the East River. When investigators come to interrogate the flight crew, Iggy fights against the clock to help the pilot uncover the truth. Max tracks down scarce medication after one of his own contracts COVID.
Max is forced to face the heartbreaking consequences of one of his policies. Bloom comes to a startling realization about Iggy.