Jackie goes undercover as an escort when she and Danny track down a serial killer who is murdering prostitutes in hotel rooms. Meanwhile, Erin meets a potential suitor at an art gallery who shares her interests.
When Detective Bell's girlfriend, Chantal (Chasten Harmon), is assaulted and her ex-husband is killed soon after, in what Holmes and Watson discover is a staged suicide, they search for one suspect behind the linked crimes. Also, as Bell fights the urge to seek his own brand of justice for Chantal, Sherlock makes a heartbreaking realization about the detective's past.
When Erin's informant is murdered, she blames herself and works to help Danny discover who killed him.
Unleashed by animal activists, a scientifically engineered beast with a ferocious appetite attacks Charlie. Walter must now come face-to-face with both his past and the creature.
Hank helps a theater legend as she deals with confusion and memory loss at Eddie's wedding. He also reconciles Eddie and Evan before the ceremony. Paige & Evan await pregnancy test results.