Separated from their team, Coulson and Mack discover a shocking secret about Mace, leaving all of S.H.I.E.L.D. in a precarious position.
Mace fights for his life while Coulson and team find themselves in a deadly cat-and-mouse game as they attempt his rescue.
Agents Sam and Billy Koenig are hunted down to get at the Darkhold book, and only Coulson and the team can save them before the clock ticks out.
Suspicion turns to paranoia when the team doesn't know who can be trusted as more LMDs infiltrate S.H.I.E.L.D.
Daisy, Mace, and the S.H.I.E.L.D. team must find a way to contain an explosive Inhuman. Meanwhile, Coulson and Mack come face-to-face with Radcliffe's inspiration for Aida.
