Lenox continues to rankle Archer as the two tackle their new roles. Ripley faces possible suspension over what really happened to Pawel.
Dr. Charles and Dr. Halstead sink their teeth into a bloodthirsty case. Dr. Marcel and Maggie throw a traditional crawfish boil for the staff. A new relationship blossoms while another is left on rocky ground.
Dr. Manning's actions with a recent patient lead to serious repercussions. April and Noah disagree over a patient who is injured after a beating. Dr. Charles is visited by a childhood friend with a surprising revelation.
After a major accident at O'Hare, the E.D. is concerned one of their own is in mortal danger. Will's proposal for a safe injection site goes to the board for consideration. Natalie and Goodwin become concerned for Gwen.
April receives unfortunate news that makes her question her future with Ethan. Dr. Charles and Maggie see tough times on the horizon. Natalie's memory from the accident starts to return.
