A desperate housewife has a potentially fatal health scare, while wedding plans and a long-awaited marriage proposal keep the residents of Wisteria Lane full of things to discuss with their neighbors.
House notices strange symptoms in a fellow inmate at the East New Jersey Correctional Facility; a clinic doctor must decide whether to risk her job by helping House.
As Castle and Beckett investigate the ritualistic murder of a young woman, they find strange symbols in the victim's apartment; Castle struggles with Alexis' decision to move in with Pi.
The BAU searches for an UnSub who may be fascinated with medical experimentation.
The team discovers striking similarities between themselves and their CGIS (Coast Guard Investigative Services) counterparts when a Navy diver seeking sunken treasure is found dead.