Two troubled women, Millie Crest and Fern Driscoll, switch identities. Millie, posing as Fern, stabs shady private eye Carl Davis in the arm in self-defense. Davis then turns up dead from poisoning of the stab wound to his arm. Millie then gets Perry to help her in return for a 38 cent retainer.
A desperate husband, trying to support his wife and daughter, escorts a drunk home after his night job, but is accused of killing him for his poker winnings.
A widow concerned with re-establishing her dead husband's reputation with his wealthy father hires Perry Mason to defend her.
A valuable Matisse painting is stolen from a museum. When the thief is found murdered, museum employee June Sinclair and her boyfriend David Lambert are charged with the crime.
An old man seems to be giving his money away, something his nephew and wife try to stop by having him committed. But once he escapes from the sanitarium, he's accused of murder.