The local authorities in Cleveland enlist the help of the BAU to assist in the pursuit of a serial killer who appears to be copying the methods used by famous murderers from the past.
A story of greed and betrayal pits Patrick Jane against a group of financiers when the CBI investigates a series of murders at a corporate retreat in the Sierra Nevada wilderness.
Gibbs and the team collaborate with an inspector for the International Atomic Energy Agency suffering from radiation poisoning, recreating his routine in an effort to figure out when the contamination took place.
Teddy is called away on another case, as Henry is brought in for emergency surgery; Derek and Meredith finally receive news about Zola; a patient experiences complications after surgery.
The Cheyennes blame an energy company for a fatal explosion on the reservation; Branch reconnects with Cady and learns valuable information that could help him in the election.