When Dr. Alicia Seberg, a government research scientist (guest star Amy Price-Francis), is exposed to a deadly toxin while at work and has only hours to live, she calls Patrick Jane and the CBI to find her murderer.
A boxer's death leads Vance to start up his own investigation, causing a sparring match with Gibbs.
Residency Director Dr. Leanne Rorish (Marcia Gay Harden) puts her four new first year residents to work immediately on their first day at Angels Memorial Hospital, in the busiest, most notorious hospital ER in the nation.
After Christa saves a woman's life, she pleads with Neal to perform a surgery that will ensure the patient's reproductive future. Also, Mario gets into a fight with a patient after he delivers a diagnosis that could imperil the man’s hockey career.
A new surgical attending Cole Guthrie (Cress Williams) joins Angels Memorial with the help of his estranged father and clashes with Leanne over their contrasting approaches to medicine. Also, Christa has a crisis of confidence in the middle of a procedure on her first infant since the loss of her son.
